Depression and anxiety can significantly impact an individual’s quality of life. In a study conducted by the Afghanistan Center for Epidemiological Studies, the association between these mental health variables, quality of life, and socio-demographic characteristics was examined among Afghan women living under the rule of the Taliban government. The findings were concerning, with a prevalence of depression symptoms at 80.6% and mild to extremely severe anxiety at 81.3%. Factors such as age, number of children, education level, traumatic events, and physical illness were associated with depression symptoms. The study highlights the urgent need for regular screening, psychological counseling services, and support for vulnerable women in Afghanistan.