Depression is a pervasive issue affecting millions worldwide, and healthcare workers (HCWs) are particularly susceptible. However, little is known about the mental health of HCWs in Afghanistan. A recent cross-sectional survey conducted in Herat province revealed alarming findings: 73.6% of the 299 participating HCWs reported depression symptoms. Factors such as low income, working in private hospitals, and cigarette smoking were associated with higher depression rates. The study emphasizes the urgent need for regular depression screening, psychological counseling services, and psychiatric treatment for Afghan HCWs. Addressing mental health concerns is crucial for both their well-being and the quality of healthcare services provided.